Medical Ultrasound Imaging
Wednesday, 8 May 2024
 Info Sheets  Out- side     | 'Mallinckrodt Inc.' Searchterm 'Mallinckrodt Inc.' found in 3 articles 1 definition [ • ] - 2 booleans [• ]Result Pages : •
Albunex and Infoson, used mainly in cardiac evaluations, are first generation one-pass-only contrast agents and have been replaced by the new-generation contrast media. Albunex and Infoson are the same sonicated human serum albumin microbubbles. Infoson is licensed and manufactured in Europe, while Albunex was produced in the USA. Albunex, an air-filled microbubble with a denatured albumin shell (modified from air-filled albumin microspheres prepared from sonicated 5% human serum albumin), was the first FDA-approved contrast agent, but is no longer in production. Cardiac shunts and valve regurgitations are often evaluated with Color Doppler Imaging (CDI), which also improved with injections of Albunex, but this agent is pressure-sensitive and does not recirculate. It is effectively a one-pass-only agent, limiting its clinical efficacy. See also First generation USCA, Echocardiography and Contrast Enhanced Ultrasound.
Drug Information and Specification
DEVELOPER
INDICATION
Contrast sonography and Doppler-echocardiography
APPLICATION
Intravenous injection
TYPE
Microbubble
SHELL - STABILIZATION
Albumin
Air
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In June 2007 Tyco International Ltd. completed the separation of its healthcare business, which is named Covidien. Mallinckrodt, Inc. is now part of Covidien Ltd. The company makes and distributes products for respiratory care; bulk and dosage pharmaceuticals, primarily for pain relief and addiction therapy; and imaging agents for magnetic resonance, ultrasound, x-ray, and nuclear medicine applications. With worldwide manufacturing and distribution facilities and sales offices, Mallinckrodt, Inc. sells its products worldwide.Albunex was one of the first marketed ultrasound contrast agents. Currently, Mallinckrodt discontinued the manufacturing and development of ultrasound contrast agents. Ultrasound Contrast Agents:
Contact Information
MAIL
Covidien Imaging Solutions
675 McDonnell Blvd. Hazelwood, MO 63042 USA
PHONE
US: (888)744-1414
International: +1-314-654-3177
FAX
+1-314-654-5380
ONLINE
•
From GE Healthcare;; Optison is the first 'second generation USCA' marketed in the US. Ultrasound contrast agents used during an ultrasound imaging procedure, enable more accurate diagnosis of the patient's heart condition. The application of Optison allows to image the endocardial borders of the heart, to see cardiac wall motion abnormalities and to guide the selection and monitoring of treatment. Optison represents a class of microbubbles with a shell formed by sonicating a solution of capsules filled with a perfluoropropane gas. The high molecular weight slows microbubble dissolution and prolongs the enhancement for several minutes. The human albumin-stabilized cavitation bubbles have a surface tension of 0.9 N/m and a surface dilatational viscosity 0.08 msP. 'August 06, 2001 Molecular Biosystems Inc., a subsidiary of Alliance Pharmaceutical Corp, announced the amendment of the Optison Product Rights Agreement (OPRA) dated May 9, 2000 with Mallinckrodt Inc, a unit of Tyco Healthcare. Optison, an intravenous ultrasound contrast agent, was developed by MBI and is being marketed by Mallinckrodt in the U.S. and Europe. Under the amended agreement, MBI will receive an immediate cash payment plus additional unspecified royalties for a two-year period. The amendment of OPRA coincides with an announcement by Nycomed Amersham Imaging that Nycomed and Mallinckrodt will terminate their joint commercialization and development agreement for ultrasound contrast agents, including Optison, effective Dec. 31, 2001. Effective Jan. 1, 2002, all selling and marketing activities will be resumed solely by Nycomed Amersham.'
Drug Information and Specification
RESEARCH NAME
FS069
DEVELOPER
INDICATION -
DEVELOPMENT STAGE LVO -
For sale APPLICATION
intravenous/oral
TYPE
AlbuminN-acetyltryptophan,Caprylic acid
CHARGE
Slight Negative
Octafluoropropane
MICROBUBBLE SIZE
93% < 10μm
PRESENTATION
Five 3ml vials
STORAGE
Refrigerate 2-8 °C
PREPARATION
Hand agitate
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Distribution Information
TERRITORY
DISTRIBUTOR
USA, EU
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[last update: 2023-11-06 01:42:00]